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Primarily localized in the endoplasmic reticulum of mammalian cells, a small fraction of PDI is also found in the nucleus, cytosol, mitochondria, plasma membrane and extracellular space 25

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Actograms and period estimates (chi-square periodogram) were acquired with Clocklab (Actimetrics)

In addition, peroxisomes contribute to the biosynthesis of essential lipid molecules, such as bile acid, cholesterol, docosahexaenoic acid, and plasmalogen