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The downregulation of SOD and upregulation of genes like MPO and HIF1 support this oxidative stress-driven mechanism

Reproduction 154 , R123R131 (2017)

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Research indicates that the timing and duration of growth hormone exposure may be critical for optimizing bone and connective tissue benefits, with pulsatile patterns potentially being more effective than continuous exposure for promoting balanced remodeling and avoiding potential adverse effects such as excessive bone turnover or joint swelling