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Core In Vitro DMPK Evaluation Systems Critical Considerations: Analysis target : For novel linkers, actual cleavage sites may differ from theoretical designs

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Known small molecules that bind to and modulate target genes and/or gene products, as well as information about the biological activities and pathways affected, are readily available from publicly available databases (e.g., drug bank, PharmGKB, MedChemExpress, and seleckchem)