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Several factors could have affected this, such as the dogs in experiment 1 performing sprint running each week as well as the endurance exercise, or experiment 1 being performed during cooler months compared with experiment 2

However, we now know that the exposome (and its influence on the epigenome) is far more significant in most cases

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In the face of foam cell buildup and excessive cell death, efferocytes can become overwhelmed, leading to the loss of atheroprotective effector functions, cell death, and the release of pro-inflammatory DAMPs, which all augment the proatherogenic environment 2