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Furthermore, NAC directly evidenced antidepressant-like effects in rodent models of depression through its role as an antioxidant (45, 46)

Luc JGY, Reddy RM, Corsini EM, Carrott PW, David EA, Shemanski K, Fabian T, McCarthy DP, Okereke I, Oliver AL, Turner SR, Vaporciyan AA, Antonoff MB, Group (TECoG) TEC

[117] demonstrated that iron overload could cause cartilage degeneration by inducing oxidative stress and mitochondrial dysfunction [117]

Together, these data indicate that pharmacological activation of lysosomal iron can trigger ferroptosis

10.2174/0929867321666140706141806 79 PaytonA.GibbonsL.DavidsonY.OllierW.RabbittP.WorthingtonJ.et al