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Recently, a high-resolution crystal structure of phosphinic pseudopeptide inhibitor 45 (DG046) in the closed-conformation of ERAP1 was disclosed (Giastas et al., 2019b) and a mechanism for antigen peptide selection by ERAP1 presented (Giastas et al., 2019a)

In addition to direct optimization, strategies involving double substrate binding and substrate envelope hypotheses have also been developed

This unique membrane structure allows the schistosome tegument to play a significant role in protecting the schistosome to survive in the host, some of which include

Provided a robust manufacturing protocol for scale-up

Park W et al (2020) Exposure to etoxazole induces mitochondria-mediated apoptosis in porcine trophectoderm and uterine luminal epithelial cells