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Description

PGC-1 is a transcriptional coactivator that interacts with several transcription factors to control the transcription of more than 150 genes encoding mitochondrial proteins involved in fatty acid oxidation, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), the mitochondrial ribosomal machinery and membrane transport

Ahmad Jamil H, Abdul Karim N

We further carried out 60-ns MD simulations with 3 replicas for PV2-C23pAcF and PV2-C96pAcF variants to understand the effect of pAcF incorporation on protein conformation, and the RMSD, RMSF, radius of gyration, the existence of hydrogen bonds and salt bridges were analyzed (Figs