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the approved IGF-1 mecasermin carries a documented hypoglycemia warning, so eating around dosing and never combining carelessly with insulin are genuine safety points [4]

It binds to GHRH receptors on somatotroph cells in the anterior pituitary, triggering intracellular cAMP accumulation and subsequent GH release

& Miller, R

Furthermore, reduced IGF-1 signaling in primary mouse astrocytes results in diminished antioxidant capacity, impaired mitochondrial structure and function, compromised ATP synthesis, increased mitochondrial ROS production, and heightened susceptibility to hydrogen peroxide-induced cytotoxicity [209]

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