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It is conceivable that genetic influences may be reflected in an endophenotype (hidden phenotype) of bipolar disorder characterized by abnormal circadian and hormonal rhythms, responses to medications, and specific gray- and white-matter changes (42, 6870)

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Other transcription factors, such as Foxo1, NF-B, and cAMP-responsive element binding protein, are also involved in the regulation of transcription of GRKs (GRK2, GRK5, GRK6) [141,142,143]

After incubating at 37 C, 5% CO 2 for 7296 h, cell growth curve is obtained by analyzing cell confluence per well

This will provide evidence to support clinical trials targeting ferroptosis and ultimately enable a full pipeline from basic mechanisms to translational tools and clinical application, ensuring that ferroptosis-based therapies progress from laboratory research to patient care