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Stage 2: Decreased levels of B12 and metabolic abnormalities such as high homocysteine or methylmalonic acid (MMA) levels

251 However, aurora kinase A (AURKA), an important mitosis regulator, increases the phosphorylation of GSK-3 and inactivates the protein destruction complex, which stimulates the upregulation of -catenin expression and promotes liver regeneration

doi: 10.1111/febs.16272 124 ChenYFangZMYiXWeiXJiangDS

By integrating the network graph and the topological attributes table, we identified five key targets associated with UC, including REN, LNPEP, HLA-A, OXTR, and SIRT1