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In recent years, emerging targeted therapies such as PCSK9 inhibitors (e.g., alirocumab, evolocumab) have shown significant LDL-lowering effects, and are particularly suitable for high-risk patients or those who are poorly tolerant to statins [209, 210]

Both the bacterium and its metabolite ILA reduced host m 6 A modification levels while upregulating cytochrome p450 family 8 subfamily b member 1 (CYP8B1) expression, thereby elevating serum CA abundance and attenuating lipid deposition in adipose tissue

Therefore, there is an urgent need to develop more sophisticated preclinical models that better mimic human physiopathology

Oshitari, T