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Transmission electron microscopy and ad-GFP-LC3B fluorescence assays revealed reduced numbers of autophagosomes in idebenone-treated cells compared to the hydrogen peroxide group, confirming that idebenone suppressed excessive autophagic activity

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The overexpression of GlcNAcase or the inhibition of GlcNAc modification increases the expression of SERCA2a, the ablated sarcoplasmic reticulum Ca 2+ leakage, improved cardiac contractility, and reduced arrhythmia events (56)

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The fusion protein also exhibited protective effect on H 2 O 2 -induced oxidative stress in HaCaT cells