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Enhanced neuronal survival and axon growth (suggested by activation of the PI3K/Akt and MAPK pathways) with lower inflammation (suggested by reduced p38 and JNK phosphorylation) were also recognized ( Finally, Several studies demonstrate that the functionalization of RADA 16-I hydrogels with bioactive motifs derived from neurotrophic factors (e.g., NGF, BDNF), angiogenic peptides (e.g., VEGF-mimetic KLT), and ECM-related sequences (e.g., IKVAV, RGD, RGI) significantly enhances peripheral nerve regeneration versus unmodified RADA or empty conduits
Research protocols explore combination approaches with other senolytic compounds such as dasatinib and quercetin, providing frameworks for studying multi-target senolytic strategies and understanding synergistic effects in various experimental models and disease research applications
