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Apart from its main substrate H 2 O 2 , the CAT enzyme could also process other oxidative species such as O 2 - , OH, 1 O 2 , hypochlorous acid (HOCl), NO, and peroxynitrite (ONOO - )

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Concurrently, repurposing disulfiraman ALDH inhibitor that has recently shown dual efficacy in quenching pyroptosis and ferroptosismay synergize with roflumilast to alleviate neutrophilic inflammation (180)

3.2.5 Extracellular vesicles and exosomes Mesenchymal stem cells (MSCs) have been investigated for their role in organ protection in sepsis and acute respiratory distress syndrome (ARDS), primarily due to their ability to secrete beneficial exosomes that can transfer mitochondria or mitochondrial components to other cells (142)