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However, macrovascular benefit was elusive in people with T2D of longer duration (7.911.5 years) in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) and Veterans Affairs Diabetes Trial (VADT) studies [35, 36], and the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study reported increased CV mortality [37]

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In comparison, anti-CXCL10 antibody might interfere with other regular tumor therapies as CXCL10 within tumor tissue binds CXCR3 to exert antitumor effect

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