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These results support the ability of DMF to attenuate ROS and ferroptosis stress in SCD erythroblasts through TSS pathway activation

10.1056/nejmoa1504720 236 ZorovaL

Apart from these intrinsic, extrinsic and stress-induced processes, there exists an additional pathway that entails T cell mediated cytotoxicity and perforin/granzyme-dependent cell death