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38 Iron overload Although iron is a helpful component of the human body and the major micronutrient in the human diet, involved in crucial cellular functions and metabolic processes, excessive iron increases the production of ROS, leading to cell dysfunction or death, tissue damage, and organ disease

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Interestingly, the variants of surface exposed residues belong to two different domains of FXN within the NFS1-ISCU-FXN complex: the region spanning Glu96 to Asp124, corresponding to the first -helix of FXN that is involved in the interaction with NFS1, and the region spanning Asn146 to Arg165 composing the -sheet that is involved in the interaction with ISCU (Figure 4D)

Furthermore, over expression of OsGSTL2 in Arabidopsis have been discern to enhance the rate of germination and causes early bolting, which explicitly suggests its involvement in plant growth and development (Kumar et al., 2013b)

This suggests that ROS detoxification mediated by GpoA, as well as AhpD and TpxD, are important for the induction of antibiotic persistence under oxidative stress conditions, which is dependent of the imported glutathione (Fig