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AnkB-deficient animals have sinus bradycardia, a prolonged QT interval, and other myocardial electrical phenotype changes, promoting myocardial mechanical remodelling as well as premature death, which is related to the low expression of -catenin in the intercalated disc and high expression in the cytoplasm caused by the loss of AnkB

Its concentration decreases significantly with age, from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60

The compound is produced as an LPS-free and endotoxin-free research peptide , making it suitable for controlled in vitro and experimental laboratory studies where endotoxin interference must be minimized