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KD therapy could be a novel, nontoxic, cost-effective adjuvant therapy for cancer patients that exploits tumor metabolic weaknesses beyond glucose/insulin signaling

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3.3.2 Protein HPX interactome from HepG2 cells Affinity chromatography using hemeHPX Affi-gel 15 and whole-cell extracts of LRP1 +/+ HepG2 cells isolated hemeHPX-binding proteins, which were identified using MS by peptide sequencing and the extent of coverage of the complete amino acid sequence

454 In addition, IL-33 derived from aged hepatic stellate cells activates ST2 Tregs, driving CD8 T-cell exhaustion and promoting the progression of obesity-associated hepatocellular carcinoma