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The full OIG Audit Report A-09-23-03014 documents the methodology

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Expected Timelines 4-8 Weeks Subtle changes in skin texture and firmness 8-12 Weeks Visible improvements in wrinkles and skin quality 12+ Weeks Optimal results with continued use Clinical evidence includes 12-week studies showing improved skin laxity, clarity, and reduced wrinkles, outperforming vitamin C and retinoic acid in comparative trials with 70% increase in skin elasticity after 12 weeks

There are some great options out there, though, that understand the importance of methylfolate and avoid the inclusion of folic acid

Interestingly, high levels of B12 in the blood can sometimes be a marker of underlying renal or liver issues rather than "too much" supplementation