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A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control

For example, targeting carnitine palmitoyl transferase 1A and protein arginine methyltransferase 5 boosts immunotherapy by activating ACSL4 and inhibiting NRF2 [Figure 2] [54,137]

The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis

By employing the safe and feasible gene-editing tool CRISPR/Cas9 to engineer T cells, this method can mitigate exhaustion-inducing signaling pathways, preserve antitumor activity, and increase the in vivo persistence of CAR-T cells, thereby further overcoming limitations in cancer therapy (Fig