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System x is a cystine/glutamate antiporter which belongs to the class of heterodimeric amino acid transporters, consisting of xCT as the specific subunit and 4F2hc as the promiscuous heavy chain (Sato et al., 1999)

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Nanoparticles can reach the tumour microenvironment and deposit inside it through passive targeting, which utilizes the aberrant vasculature of cancerous cells [177, 178]