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Apoptosis of uterine leiomyoma cells was also stimulated by the expression of caspase-3, an important mediator for apoptosis, and by caspase-9, an initiator of apoptosis (Malik et al., 2009)

NNMTi-mediated changes to the availability of nicotinamide/nicotinic acid in conjunction with the presence of moderate amounts of Lactobacillus may promote a positive feedback loop further increasing the abundance of Lactobacillus

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The dose was well-tolerated, and no adverse events were reported