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In the nineteenth century, Russian physicians documented its health-promoting effects, including immune modulation, antimicrobial activity, lactose digestion, cholesterol metabolism, and possible anticancer properties

[314] A moderate dose of caffeine enhances rapid eye movements' kinematics, such as saccade velocities and quick phases of optokinetic nystagmus, in unfatigued individuals, without affecting pursuit eye movements or visual perception, suggesting that caffeine's influence on oculomotor control may be mediated by changes in central catecholamines even in non-fatigued conditions

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And finally, subunit vaccines can constitute viral proteins incorporated in synthetic nanomaterials, protein cages and VLPs, which serve as adjuvants and/or delivery vehicles, in addition to conferring other benefits inherent to each nanocarrier platform 55,56,57