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If incubation with compounds is prolonged, superior efficacies can be reached: after 72 h exposure of NTS to compounds 1 and 6 had LD 50 s of 2.2 0.19 and 7.8 2.36 M respectively, whereas 2 had 0.18 0.007 M

Furthermore, considering the pivotal role of CPT1A in oxidative metabolism and cellular redox state, we proceeded to assess the level of ROS, which are known to influence cell survival

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Cellular levels of GSH are maintained by GSH reductase catalyzing the reduction of oxidized GSH, which forms the dimer glutathione disulfide (GSSG) and thus regenerates GSH

When this ratio drops (meaning you have too much NADH and not enough NAD+), your metabolism stalls