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Thanks for any thoughts, Kelly Since hormetic compounds display a U-shaped biphasic dose-response curve, meaning that at low/optimal doses they improve health and have a reverse tolerance effect (get more powerful with frequent use), but at high doses have detrimental effects, Im wondering whether or not many of the supplements on the market containing high doses of these compounds (Like EGCG, Curcumin, and Resveratrol) are dangerous

Using glutathione (GSH) as a cosubstrate, specifically the most abundant tau (GSTU) and phi (GSTF) isoenzymes may diminish the GSH pool, thereby influencing various redox-dependent processes (Marrs 1996

However, the way we absorb glutathione can significantly affect its efficacy

This medication was recently approved by the Food and Drug Administration (FDA) for active, moderate-to-severe TAO, suggesting that ferroptosis may contribute to TAO progression and may become a new therapeutic target

The effect is selective muscle preservation rather than anabolic growth, perfectly aligned with the goal of pure fat reduction