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Experimental data suggest that this catalysis occurs under the influence of GS, FAD, NADPH, and FMN [90]

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In some embodiments, the term alkylene may include (CH 2 )n- where n is 2-8

Key features: Copper coordination at the histidine imidazole the histidine ring nitrogen is the primary copper-binding site Additional copper coordination via amine groups the lysine side chain and N-terminal amine participate in the copper binding pocket Square-planar copper geometry the copper(II) ion sits in a defined geometric configuration that determines activity Naturally occurring same molecular structure as the GHK-Cu found in human plasma, just synthesized for research-grade purity The copper coordination is what gives GHK-Cu most of its activity research has documented different activity profiles for GHK alone versus GHK-Cu