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These hydroxyl radicals induce lipid peroxidation, protein oxidation, and DNA damage, ultimately contributing to the initiation and progression of atherosclerosis ( Moreover, copper deficiency may also augment mitochondrial oxidative stress by suppressing COX (complex IV) activity, which impairs electron transport chain function and secondarily increases ROS formation (Johnson and Thomas, 1999)

doi: 10.1038/s42255-018-0003-x 127 MoonJSda CunhaFFHuhJYAndreyevAYLeeJMahataSKet al

Genetic disorders of manganese metabolism

Brosnan JT, Williamson DH (1974) Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride

Weidenfeller, C., Svendsen, C