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Gaudet et.al [27] managed to induce tumorigenesis in mice by genomic hypomethylation, which validated the correlation between genomic hypomethylation and tumorigenesis

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Gpx4-deficient T cells from specific knockout mice rapidly accumulate lipid peroxides upon activation, leading to ferroptosis ( Therapeutic strategies targeting ferroptosis Small molecules to induce ferroptosis in cancer System Xc plays a significant role in the survival and growth of many tumor cells, making it a potential target for cancer treatment

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