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However, a small number of people reported inflammation at the injection site when sterile water was used to dilute peptides that were supposed to be injected intramuscularly

In situ cancer vaccines initiate a broad polyclonal T-cell response by exposing the immune system to a wide array of tumor antigens released from local tumor cell death, thereby reducing the likelihood that antigen-loss variants can evade immune detection since multiple tumor neoantigens are targeted simultaneously

As explained in the CY 2016 PFS final rule with comment period (80 FR 70933), we recognize that adjusting work RVUs for changes in time is not always a straightforward process, so we have applied various methodologies to identify several potential work values for individual codes