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It was suggested that the differentiated production of IL-1 and IL-8 may be linked to the type of product applied, either an irritant or a sensitizer 39,40

International Journal of Biological Macromolecules, 253 , 127554

These modifications grant it pharmacokinetic properties absent in peptides oral bioavailability, protease resistance, and efficient blood-brain barrier penetration but also mean its metabolic fate and tissue distribution may differ substantially from peptide-class compounds

Maximal effects typically occur at four to six weeks, with full tissue remodeling continuing over three to six months

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