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In regions affected by cardiac infarction, overexpressed MMP-2/9 can cleave the TIMP peptide like bFGF and GST, facilitating the on-demand release of bFGF [343]

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260,261 Owing to its rate-limiting enzymatic activity in NAD + salvage pathway, the elevated expression of NAMPT in the innate immune cells, including macrophages and dendritic cells, further proposed a link between intracellular NAD + levels and inflammation

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