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You follow a plant-based, vegan, or vegetarian diet and may be at risk for B12 or D3 deficiency

Effects of vitamin B12 on performance and circadian rhythm in normal subjects

Mayo Clinic Drugs & Supplements (2025) 7

Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism