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If dark circles are due to excess melanin or vascular discoloration, other treatments like laser therapy or PRP may be more effective

For LiCl-exposed cells with co-treatment with CHX, Swan 71 cells were firstly treated with 10 mM LiCl for 48 h and then treated with 10 M CHX for another 0, 2, 4, 6, or 8 h