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To build the R615C pig RyR1 open structure in complex with atorvastatin, we used the open rabbit RyR1:atorvastatin complex, modified by the program MODELER 55 to update pig-specific side chains, followed by rigid body refinement and several rounds of PHENIX real space refinement and ISOLDE

al., Skeletal Muscle Signaling Following Whole-Body and Localized Heat Exposure in Humans, Frontiers in Physiology, VOLUME 11, 2020 Chang M, Ibaraki T, Naruse Y, Imamura Y

Hormone Signaling and Receptor Pharmacology AOD 9604 is frequently used to investigate selective peptide signaling and receptor pharmacology

The SARS-CoV-2 spike protein can induce severe oxidative stress, triggering the release of pro-inflammatory cytokines in what is often described as a localized cytokine storm

Strikingly, we found that TDP-43 SUMOylation was selectively modified by SUMO2 and SUMO3, but not SUMO1, specifically under stressed conditions