Preclinical evidence further suggests that A 2A receptor antagonists can synergize with existing therapies like levodopa while potentially mitigating troublesome side effects such as dyskinesias
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Accordingly, apoE2 brain exhibited the highest glucose uptake rate indicated by high levels of the proteins Igf1, insulin receptor substrates (Irs) and glucose transporter 4 (Glut4), that is consistent with the protection conferred by the apoE2 isoform [64]
In particular, a notable reduction was observed in the level of glutaminase (GLS), an enzyme responsible for catalyzing glutamine to glutamate
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