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According to research on real-world sequential therapies, even after numerous treatment attempts, almost 30% of MDD patients do not experience remission

Assoc., 2020, doi: 10.1001/jama.2019.18714

The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is a master regulator of cellular antioxidant responses, orchestrating the expression of cytoprotective genes like heme oxygenase-1 (HO-1) (Osburn and Kensler, 2008

5 But, when CPZ doses were properly controlled, the NLY01 was no longer effective in reducing demyelination or improving remyelination

The amplified sequences were inserted into the suicide vector pSDUDI after digestion with appropriate restriction enzymes