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doi: 10.1155/2022/6177553 52 WuYPiDZhouSYiZDongYWangWet al

We discuss translational considerations for multipathway strategies and outline design principles for multifunctional nanoplatforms, including multiligand surface functionalization and combinatorial payloads, which collectively realize a systems-level nanomedicine framework for AD

Moreover, several studies have shown a link between neuroinflammation and the augmentation of the GSK-3 activity and in parallel the decrease of the WNT/-catenin pathway and the protein kinase B (Akt) pathway (Fig

Our findings highlight necroinflammation as a critical integrative framework through which regulated cell death and immune responses jointly determine tissue injury and functional outcome