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The bottom-up strategy for particle construction mainly includes the use of a massive number of targeting ligands derived from living systems

The Absence of Robust Human Clinical Evidence Despite widespread interest, there is a stark reality: there are no large-scale, randomized controlled human trials evaluating BPC-157 for musculoskeletal or systemic healing

doi:10.1016/0196-9781(86)90148-7 PMID: 3550877 8

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Liu H, Wang Y, Zhang W, Sun W, Ji X, Zhang S, Qiao K (2022) Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans