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Hyaluronic Acid is an essential component of the macromolecules that provide structural support for the tissues and organs of the body, called the extracellular matrix

However, this effect was reversed by the SIRT1 inhibitor NAM

Furthermore, sesamin-treated mice maintained higher levels of endogenous antioxidants for example, superoxide dismutase (SOD) activity was increased relative to untreated MPTP mice, and striatal TH levels were better preserved, indicating reduced dopaminergic neuron damage (66)