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Together, these emerging agents represent a significant shift in antifungal therapy, expanding treatment options beyond traditional mechanisms, addressing current resistance gaps, and offering improved pharmacological and patient-centered profiles

A.VassalloJ.et al

197 For instance, increased blood urea concentrations can alter the microbiome, resulting in the increased generation of toxic metabolites from the gastrointestinal tract as well as an increased tendency for toxins to cross the gut barrier, which can promote further kidney injury

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This finding is also likely to occur in other tissues, including the kidney