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A previous study showed that NEMO dimerization via disulfide bonds and subsequent NF-B signaling after TNF stimulation in mouse embryonic fibroblasts (MEF) depended on two redox-sensitive cysteines, Cys 54 and Cys 374 , [40] and, indeed, expression of a redox-insensitive NEMO mutant in PM, BMDM and MEF through transfection of in vitro-generated mRNA [123] completely abolished disulfide linkage of NEMO, proinflammatory signaling and cytokine secretion in response to bacterial infection

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CiteSpace and VOSviewer were used for bibliometric analysis, including cluster analysis, co-occurrence analysis, co-citation analysis, and burst analysis of countries/regions, institutions, journals, authors, references, and keywords

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