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Moreover, a growing body of evidence suggests that p53 regulates ferroptosis either by transcriptional or posttranslational mechanisms such as modulating the downstream expression of SLC7A11 , 239 SAT1 (encoding spermidine/spermine N1-acetyltransferase 1), 240 GLS2 (encoding glutaminase 2), 25 and CDKN1A/p21 (encoding cyclin dependent kinase inhibitor 1A), 241 or by directly inhibiting DPP4 activity in colorectal cancer cells