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Six replicates from each group were used for this assay

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Structural features of Cagri-bound active CTR complexes Previous structural analysis of CTR-Gs bound to rAmy revealed that the receptor complex was dynamic, adopting distinct states where the receptor was resolved into two major conformations, a bypass (55%, PDB: 7TYL) and CT-like (45%, PDB: 7TYI) conformation 15

Four patients fulfilled the criteria for definite adultonset leukoencephalopathy with axonal spheroids and pigmented glia due to CSF1R mutations, defined by Konno et al