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FIGURE 1 2.1 DNA methylation DNA methylation is a fundamental epigenetic modification that regulates gene expression by adding a methyl group to cytosine residues, primarily at CpG islands within gene promoter regions ( TP53 , CDKN2A , and MLH1 , leads to transcriptional silencing, contributing to leukemogenesis and resistance to apoptosis

The structures were validated using Whatcheck 50 , Molprobity 51 and Pavarti 52

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Available from: Mechler et al (2022): Evidence-based pharmacological treatment options for ADHD in children and adolescents

In certain embodiments of the ingestible article, the exterior surface material comprises a polymeric material