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The convergence of these influences suggests that disruptions in microbial homeostasis could contribute significantly to the development and perpetuation of ME/CFS [10, 33]

As such, an ACO's MIPS Quality performance category score is calculated according to MIPS scoring rules for the Quality performance category established at 414.1380(b)(1) with exceptions for (1) measures that do not have a benchmark or do not meet the case minimum requirement and (2) measures that are identified as topped out

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As mentioned, ROS are naturally produced in the mitochondria