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2023;5 doi: 10.1093/nargab/lqad082

In addition, the optimal protocols (regarding dosage, timing, and duration) for using natural products alone or in combination with existing therapies have not been determined, and their potential synergistic mechanisms require further elucidation

Final DAR value is calculated as described in Xu et al., Anal

However, ablation of LDHA in CD8 T cells severely impairs their activation, clonal expansion and effector function, primarily due to insufficient ATP production needed to sustain PI3K signaling [76]