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Pyridoxine (vitamin B6) is sometimes combined for additional metabolic and nervous system support

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In a study published in the American Journal of Mens Health, long-term secretagogue therapy that included GHRP-based peptides showed increased serum IGF-1 concentrations in hypogonadal men after consistent dosing, indicating that GH secretagogues can enhance the GH-IGF-1 axis over time, a pathway linked mechanistically to recovery and anabolic effects