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Systematic reviewers could search for unpublished trials and results

doi: 10.1016/j.micinf.2011.06.012 228 ChanJXingYMagliozzoRSBloomBR

The compound discussed here is investigational, and the published research on it is largely preclinical

In contrast to the aforementioned sodium channel-targeting peptides, BmK-YA specifically interacts with opioid receptors, demonstrating binding affinity for -, -, and -opioid receptor subtypes (Yan et al., 2012)

found that AS intervention group exhibited a significant increase in intestinal microbial diversity (primarily Lactobacillus ), compared to the cirrhosis model group, and resulted in a deceased incidence and quantity of BT, contributing to the protection of the intestinal barrier, reduction of inflammation, and mitigation of liver injury