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Targeting strategies for chemotherapy-induced peripheral neuropathy: does gut microbiota play a role

Unbiased sub-clustering of these cells revealed seven distinct cell types (Figs

In calves, Sertoli cells, Se improved cell viability and expression of bloodtestis-barrier proteins (occludin, connexin-43, zonula occluden, E-cadherin) by modulating the expression of mitochondria-related genes, inhibiting the nuclear factor kappa B (NFB) activation of inflammatory cytokines and apoptosis, and increasing the GPX4 activity (160, 161)

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MOTS-c activates AMPK (AMP-activated protein kinase), which signals cells to shift from glucose storage to fat oxidation and improves insulin sensitivity through mitochondrial and nuclear gene regulation